| 摘要 |
Disclosed are furo[3,2-d]pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein, W is O; X is O, NH, S, SO or SO2; Y is hydrogen, halogen, alkyl or alkoxy; A and B are each independently hydrogen atom, halogen atom, or di(alkyl)aminomethyl; Z is optionally substituted aryl or optionally substituted heteroaryl; optionally, the alkyl is partially unsaturated or has a cycloalkyl moiety. Representative compounds include N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-morpholinophenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-((dimethylamino)methyl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-((4-(dimethylamino)piperidin-1-yl)methyl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((3-fluoro-4-(1-methylpiperazin-4-l)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-(2-dimethylamino)ethyl)amino)-3-fluorophenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((3-fluoro-4-((1-methylpiperidin-4-yl)amino)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-(2-(3-methoxy-4-(4-methyl-piperazin-1-yl)-phenylamino)-furo[3,2-d]pyrimidin-4-yloxy)-phenyl)-acrylamide and N-(3-((2-((4-sulfamoylphenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide. Further disclosed is a pharmaceutical composition for preventing or treating cancers, tumours, inflammatory diseases, autoimmune diseases, or immunologically mediated diseases which comprises the compound of formula (I) as defined above or its pharmaceutically acceptable salt as an active ingredient. |
