发明名称 |
PREPARATION OF CHIRAL 1-METHYL-2,3,4,5-1H-BENZODIAZEPINES VIA ASYMMETRIC REDUCTION OF ALPHA-SUBSTITUTED STYRENES |
摘要 |
The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates. |
申请公布号 |
WO2014202765(A1) |
申请公布日期 |
2014.12.24 |
申请号 |
WO2014EP63048 |
申请日期 |
2014.06.20 |
申请人 |
LEK PHARMACEUTICALS D.D. |
发明人 |
STAVBER, GAJ;GAZIC SMILOVIC, IVANA;CLUZEAU, JEROME;RICHTER, FRANK |
分类号 |
C07D223/16;C07C67/03;C07C69/635;C07C201/12;C07C205/09;C07C209/34;C07C209/48;C07C211/29;C07C217/40;C07C233/18;C07C253/30;C07C255/10;C07C311/17 |
主分类号 |
C07D223/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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