| 摘要 |
<p>The disclosure relates to methods for synthesizing PPAR( sparing compounds, particularly thiazolidinedione derivatives of formula (I), wherein the variables are as defined in the specification. Peroxisome Proliferator Activated Receptors (PPARs) are members of the nuclear hormone receptor super-family, which are ligand-activated transcription factors regulating gene expression, thus PPAR( is the generally accepted site of action for insulin sensitizing thiazolidinedione compounds, which makes these thiazolidinedione compounds useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, dyslipidemia, and inflammatory diseases.</p> |
