METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES
摘要
A composition including a Rh or Ru metalloinsertor complex specifically targets mismatch repair (MMR)-deficient cells. Selective cytotoxicity is induced in MMR-deficient cells upon uptake of the inventive metalloinsertor complexes.
申请公布号
EP2707377(A4)
申请公布日期
2014.12.24
申请号
EP20120782602
申请日期
2012.05.10
申请人
CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人
BARTON, JACQUELINE, K.;KOMOR, ALEXIS;SCHNEIDER, CURTIS, J.;WEIDMANN, ALYSON;ERNST, RUSSELL
