Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies

摘要

Disclosed is a stable liquid pharmaceutical formulation comprising: (i) a human antibody that specifically binds to human interleukin-4 receptor alpha (hIL-4Rα), wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:1 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:5; (ii) acetate at a concentration of from 10 mM to 15 mM; (iii) histidine at a concentration of from 15 mM to 25 mM; (iv) sucrose at a concentration of from 2.5% w/v to 10% w/v; (v) polysorbate at a concentration of from 0.1% w/v to 0.3% w/v; and (vi) arginine at a concentration of from 25 mM to 100 mM, wherein the formulation has a pH of from 5.6 to 6.2.