SCREENING METHODS FOR THROMBIN BINDING AGENT AND USES OF THROMBIN BINDING AGENT FOR INHIBITING OR PREVENTING COAGULATION

摘要

The invention in one aspect encompasses a method of obtaining a5 thrombin binding agent which inhibits thrombin activity but causes minimal or no inhibition of haemostasis and/or causes minimal or no bleeding, the method comprising the steps of: (1) contacting a test antigen binding agent with a molecule comprising an epitope as defined herein; and (2) determining10 whether the test antigen binding agent binds specifically to the epitope. Thrombin binding agents obtained or obtainable using the method, and the use of such thrombin binding agents, is also.