发明名称 |
MATERIALS FOR POSITIVE CATHEPSIN B MODULATION AND METHODS OF USE FOR TREATING MILD COGNITIVE IMPAIRMENT (MCI), EARLY DEMENTIA, A-SYNUCLEINOPATHY, TRAUMATIC BRAIN INJURY, CARDIOMYOPATHY, EYE DISEASE AND SKIN DAMAGE |
摘要 |
The present invention provides methods for treating a subject afflicted with i) Mild Cognitive Impairment (MCI), ii) early dementia, iii) early a-synucleinopathy, iv) traumatic brain injury, v) cardiomyopathy, vi) eye disease, or vii) skin damage, comprising administering to the subject at least one compound that increases the level of active cathepsin B in cells of the subject, or a pharmaceutically acceptable salt or ester thereof, in an amount that is effective to treat the subject. The present invention also provides compositions for treating a subject afflicted with i) Mild Cognitive Impairment (MCI), ii) early dementia, iii) early cx-synucleinopathy, iv) traumatic brain injury, v) cardiomyopathy, vi) eye disease, or vii) skin damage. |
申请公布号 |
WO2014204956(A1) |
申请公布日期 |
2014.12.24 |
申请号 |
WO2014US42728 |
申请日期 |
2014.06.17 |
申请人 |
UNIVERSITY OF NORTH CAROLINA AT PEMBROKE;BAHR, BEN, A.;IKONNE, UZOMA, S. |
发明人 |
BAHR, BEN, A.;IKONNE, UZOMA, S. |
分类号 |
A61K38/43 |
主分类号 |
A61K38/43 |
代理机构 |
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