发明名称 |
Methods of enhancing drug delivery and effectiveness of therapeutic agents |
摘要 |
<p>Disclosed are methods of enhancing the uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. Also disclosed is a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as“the drug uptake capability”).</p> |
申请公布号 |
NZ602635(A) |
申请公布日期 |
2014.12.24 |
申请号 |
NZ20110602635 |
申请日期 |
2011.03.28 |
申请人 |
ABRAXIS BIOSCIENCE LLC |
发明人 |
DESAI NEIL P;SOON-SHIONG PATRICK |
分类号 |
A61K31/337;A61K9/14;A61P35/00 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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