| 发明名称 |
PRODUCTION OF PROTEINS BY AUTOPROTEOLYTIC CLEAVAGE |
| 摘要 |
The present invention relates to a process for the production of a heterologous polypeptide with homogeneous N-terminus in a bacterial host cell, wherein the heterologous polypeptide is autoproteolytically cleaved from an expressed fusion protein which comprises a polypeptide with the autoproteolytic activity of an autoprotease N<SUP>pro </SUP>of a pestivirus and the heterologous polypeptide by the N<SUP>pro </SUP>autoproteolytic activity. |
| 申请公布号 |
EP1200603(B1) |
申请公布日期 |
2014.12.24 |
| 申请号 |
EP20000954596 |
申请日期 |
2000.08.07 |
| 申请人 |
SANDOZ AG |
发明人 |
RÜMENAPF, TILLMANN;THIEL, HEINZ-JÜRGEN;WINDISCH, JÖRG;KNAUSEDER, FRANZ |
| 分类号 |
C12N15/09;C12N15/57;C07K14/54;C07K14/56;C07K19/00;C12N1/21;C12N9/48;C12N9/50;C12N15/62;C12N15/70;C12P21/02;C12P21/06;C12R1/19;C12R1/93 |
主分类号 |
C12N15/09 |
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