5T4-TARGETED IMMUNOFUSION MOLECULE AND METHODS

摘要

Immunofusion molecules useful for 5T4-targeted therapy. The immunofusion molecules include the 5T4 antigen-binding portion of an anti-5T4 antibody engineered into a single chain form and fused to a cytotoxic payload, such as, human pancreatic RNase ("HPRN"). The RNase portion of the single immunofusion peptide may be fused to a polyglutamic acid (polyE) tail. A pharmaceutical composition includes an immunofusion molecule including a 5T4 antigen-binding portion and HPRN and methods of administering the composition to an animal in need.