发明名称 |
COMPOSTIONS AND METHODS FOR ENHANCING THE THERAPEUTIC POTENTIAL OF STEM CELLS |
摘要 |
The invention encompasses compositions and method of treating a vascular disease such as peripheral artery disease, The methods involve- administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (MSCs) and a non-muscle myosin 0 antagonist such as blebbistatin. Non-muscle myosin II antagonists are disclosed to surprisingly and dramatically accelerate MSC-triggered regeneration of damaged tissues arid unexpectedly and drastically reduce severe complications of stem cell treatment. |
申请公布号 |
WO2014140930(A3) |
申请公布日期 |
2014.12.24 |
申请号 |
WO2014IB01248 |
申请日期 |
2014.03.13 |
申请人 |
LONZA COLOGNE GMBH |
发明人 |
VAN DEN BOS, CHRISTIAN;REINISCH, BARBARA;SCHENK, JUDITH;ROSENBAUM, CLAUDIA |
分类号 |
A61K31/437;A61K35/28 |
主分类号 |
A61K31/437 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|