发明名称 |
MULTISTAGE FORMULATION CONTAINING A BIGUANIDE AND A THIAZOLIDINEDIONE DERIVATIVE |
摘要 |
<p>A method of preparing a pharmaceutical dosage form having a first and second active drug, comprising
(a) forming a controlled release core comprising metformin or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient;
(b) coating a coating solution on said controlled release core to form an immediate release coating, said coating solution comprising:
(i) pioglitazone or a pharmaceutically acceptable salt thereof;
(ii) water;
(iii) an organic solvent;
(iv) a binder;
(v) optionally a surfactant;
(vi) optionally a pore forming agent;
wherein the ratio of water to organic solvent is 50:50 to 2:98, and the ratio of binder to pioglitazone or the salt thereof is 1:9 to 1:11;
wherein said dosage form releases not less than 75% of the pioglitazone or the salt thereof from the dosage form within 0.5 hour when tested in a United States Pharmacopeia (USP) Type 2 apparatus at 75 rpm in 900 ml of simulated intestinal fluid (pH 7.5 phosphate buffer) and at 37°C.</p> |
申请公布号 |
EP1539144(B1) |
申请公布日期 |
2014.12.24 |
申请号 |
EP20030754689 |
申请日期 |
2003.09.19 |
申请人 |
ANDRX LABS LLC |
发明人 |
LODIN, UNCHALEE;NANGIA, AVINASH;CARDINAL, JOHN;GOLDFARB, ROBERT, I. |
分类号 |
A61K9/00;A61K9/22;A61K9/24;A61K9/28;A61K31/155;A61K31/425;A61K31/426;A61K45/06 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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