TREATMENT OF BRAIN CANCER WITH ONCOLYTIC ADENOVIRUS
摘要
The present disclosure involves compositions and methods for treating brain cancers having mutations in the retinoblastoma (Rb) pathway using an oncolytic adenovirus comprising an alteration in the Rb binding site of El A, and a targeting motif inserted in the Ad fiber protein. The adenovirus is able to kill the tumor cells without harming cells with a wild-type retinoblastoma pathway.
申请公布号
WO2014204814(A1)
申请公布日期
2014.12.24
申请号
WO2014US42375
申请日期
2014.06.13
申请人
DNATRIX, INC.;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人
FUEYO, JUAN;MANZANO-GOMEZ, CANDELERIA;CONRAD, CHARLES;LANG, FRED;YUNG, W.K., ALFRED;TUFARO, FRANK