| 发明名称 |
Process |
| 摘要 |
The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6α-oxycodol in an amount ≦about 0.800 area % as determined by HPLC. |
| 申请公布号 |
US8916707(B2) |
申请公布日期 |
2014.12.23 |
| 申请号 |
US201313957943 |
申请日期 |
2013.08.02 |
| 申请人 |
Johnson Matthey Public Limited Company |
发明人 |
Archer Nicolas;Young Maureen;Davies Timothy;Price Amy;Bease Michael;Jamieson Barbara;Grant Ewart;Heinrich Brian;Matharu Saroop |
| 分类号 |
C07D489/08;C07D489/02 |
主分类号 |
C07D489/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6α-oxycodol in an amount ≦about 0.800 area % as determined by HPLC. |
| 地址 |
London GB |
