Method for the treatment of T cell mediated conditions by depletion of ICOS-positive cells in vivo

摘要

The present invention relates generally to binding agents useful in the selective depletion of T cells in vivo. More specifically, the invention relates to ICOS-binding agents which once bound to ICOS expressed on the surface of cells, in particular ICOS-bearing activated T cells, result in the in vivo depletion of cells to which they are bound. Methods of treating T cell related diseases using said ICOS-binding agents, and pharmaceutical compositions comprising said ICOS-binding agents, a method of identifying an ICOS-binding agent, and monoclonal anti-ICOS antibodies capable of eliminating cells in vivo which express ICOS on their surface are also provided.

主权项

1. A method of treating a T cell mediated allergic, inflammatory, or autoimmune disease, said method comprising administering to a patient an anti-ICOS antibody, or an ICOS-binding fragment thereof, wherein said antibody, or binding fragment thereof, once bound to ICOS expressed on the surface of cells results in the in vivo depletion of the cells to which it is bound.