| 摘要 |
Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I):;
including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, A, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. |
| 主权项 |
1. A compound having the following structure (I):or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof,
wherein:
A is —CR1— or —N—;X is substituted aryl or substituted heteroaryl;Y is halogen, optionally substituted alkylamino, optionally substituted alkoxy, optionally substituted thioalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, —O(optionally substituted cycloalkyl), —O(optionally substituted heterocyclyl) or —O(optionally substituted aryl);each R1 is, independently, hydrogen, halogen, C1-6alkyl or C1-6haloalkyl;R2 is —C(═O)NR2aR2b, —NR2aC(═O)R2b, —C(═O)R2b, —NR2aR2b, —OR2b or —R2b;R2a is hydrogen or optionally substituted C1-6alkyl; andR2b is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl. |
