发明名称 Pharmaceutical compounds
摘要 Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders.
申请公布号 US8916537(B2) 申请公布日期 2014.12.23
申请号 US201313961905 申请日期 2013.08.08
申请人 Aposense Ltd. 发明人 Ziv Ilan;Grimberg Hagit
分类号 C07D491/22;C07H19/06;C07D239/10;C07D403/04 主分类号 C07D491/22
代理机构 Pearl Cohen Zedek Latzer Baratz LLP 代理人 Pearl Cohen Zedek Latzer Baratz LLP
主权项 1. A method of treating cancer in a subject in need comprising administering to the subject a therapeutically effective dose of compound represented by the structure set forth in Formula (II)in which R3 is selected from the group consisting of hydrogen, C1, C2, C3, C4, C5, C6, C7 and C8 linear and branched alkyl; L is selected from the group consisting of C1, C2, C3, C4, C5, C6, C7 and C8 linear, branched and cyclic alkyl, C1, C2, C3, C4, C5, C6, C7 and C8 linear, branched alkyl-amine, piperidinyl, aryl, and a combination thereof; U is selected from the group consisting of —O—; —(CO)O—; —O(CO)—NH—; and —(CO)—NH—; D is an anticancer drug; andpharmaceutically acceptable salts, hydrates, solvates and metal chelates of the compound.
地址 Petach-Tikva IL