| 发明名称 | Method for treating microbial infections | ||
| 摘要 | A method for treating a microbial infection or an abscessed tissue in a subject includes administering to the subject an effective amount of a metal ion chelator. In some embodiments, the metal ion chelator can be a protein, such as a calprotectin heterodimer. In some embodiments, the metal ion chelator is a calprotectin heterodimer including an S100A8 polypeptide and an S100A9 polypeptide. | ||
| 申请公布号 | US8916163(B1) | 申请公布日期 | 2014.12.23 |
| 申请号 | US200812341848 | 申请日期 | 2008.12.22 |
| 申请人 | Vanderbilt University | 发明人 | Skaar Eric;Corbin Brian |
| 分类号 | A61K39/00;A61K39/38 | 主分类号 | A61K39/00 |
| 代理机构 | Stites & Harbison PLLC | 代理人 | Stites & Harbison PLLC ;Decker Mandy Wilson |
| 主权项 | 1. A method for treating a microbial infection or an abscessed tissue in a subject, comprising: administering to the subject an effective amount of a manganese ion (Mn2+) chelator, wherein the manganese ion chelator is bound with Ca2+ before administration, and wherein the manganese ion chelator is administered at or near a site of infection or a site associated with a risk of infection. | ||
| 地址 | Nashville TN US | ||