Bladder cancer diagnosis composition containing APE1/Ref-1 and bladder cancer diagnostic kit using same

摘要

Provided are a bladder cancer diagnosis composition containing APE1/Ref-1, a bladder cancer diagnostic kit containing an antibody which specifically binds to the APE1/Ref-1, and a method of measuring APE1/Ref-1 concentration in biological samples through an antigen-antibody binding reaction using the antibody which specifically binds to the APE1/Ref-1. According to the invention, the APE1/Ref-1 protein concentration in serum of bladder cancer patients is significantly higher than in healthy subjects, and more particularly, it significantly increases in the serum of patients with stage 2 or later bladder cancer.

主权项

1. A method of diagnosing a bladder cancer, the method comprising;
binding a capture antibody to APE1/Ref-1 in blood, the blood being collected from a bladder cancer patient; detecting the APE1/Ref-1 bound to the capture antibody using a detection antibody; measuring a concentration of the APE1/Ref-1 in the blood using the detected APE1/Ref-1; and diagnosing a bladder cancer based on the measured APE1/Ref-1 concentration.