| 发明名称 |
Botulinum neurotoxin antigenic compositions and methods |
| 摘要 |
Methods and compositions pertaining to botulinum neurotoxin (BoNT) light chain epitopes are provided. In particular, the methods and compositions relate to the use of real and mimetic BoNT light chain epitopes for generating an immune response in a subject, and for immunization against BoNT toxicity. Methods and compositions for detecting, isolating, and purifying BoNT epitopes and anti-BoNT antibodies are also provided. |
| 申请公布号 |
US8916162(B2) |
申请公布日期 |
2014.12.23 |
| 申请号 |
US201113579853 |
申请日期 |
2011.02.18 |
| 申请人 |
|
发明人 |
Zdanovsky Alexey Gennadievich |
| 分类号 |
A61K39/38;A61K39/40;A61K39/385;A61K39/116;A61K39/08;A61K39/00 |
主分类号 |
A61K39/38 |
| 代理机构 |
Foley & Lardner, LLP |
代理人 |
Foley & Lardner, LLP |
| 主权项 |
1. An antigenic composition comprising: a fusion protein comprising a carrier peptide and at least one epitope, wherein the carrier peptide is selected from the group consisting of Receptor Associated Protein (RAP) and Clostridium perfringens α-toxin, and wherein the epitope comprises a botulinum neurotoxin (BoNT) epitope or a mimetic BoNT epitope capable of eliciting an immune response in a human or animal subject. |
| 地址 |
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