发明名称 |
Compositions and methods for the therapy and diagnosis of influenza |
摘要 |
The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides. |
申请公布号 |
US8916160(B2) |
申请公布日期 |
2014.12.23 |
申请号 |
US201213372870 |
申请日期 |
2012.02.14 |
申请人 |
Theraclone Sciences, Inc. |
发明人 |
Grandea, III Andres G.;King Gordon;Cox Thomas C.;Olsen Ole;Mitcham Jennifer;Moyle Matthew;Hammond Phil |
分类号 |
A61K39/00;A61K39/42;A61K39/145;G01N33/569;C07K16/10 |
主分类号 |
A61K39/00 |
代理机构 |
Cooley LLP |
代理人 |
Cooley LLP |
主权项 |
1. A composition comprising:
(a) an isolated human monoclonal antibody, wherein said antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 771 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 778; and (b) an isolated human monoclonal antibody, wherein said antibody comprises a VH CDR1 region comprising the amino acid sequence of NYYWS (SEQ ID NO: 72); a VH CDR2region comprising the amino acid sequence of FIYYGGNTKYNPSLKS (SEQ ID NO: 74); a VH CDR3 region comprising the amino acid sequence of ASCSGGYCILD (SEQ ID NO: 76); a VL CDR1 region comprising the amino acid sequence of RASQNIYKYLN (SEQ ID NO: 59); a VL CDR2 region comprising the amino acid sequence of AASGLQS (SEQ ID NO: 61); a VL CDR3region comprising the amino acid sequence of and QQSYSPPLT (SEQ ID NO: 63), wherein at least one of the antibodies is directly conjugated to either a detectable label or therapeutic agent. |
地址 |
Seattle WA US |