| 发明名称 | FGF-9 variants and methods of use thereof | ||
| 摘要 | A method of treating an individual (i) having abnormal bone; or (ii) afflicted with a disease or disorder related to normal or abnormal FGF receptors or a skeletal disorder; or (iii) having dysplasic bone. The method includes administering to the individual a pharmaceutical composition comprising a therapeutically effective amount of a fibroblast growth factor 9 (FGF-9) variant comprising at least one amino acid substitution in the beta 8-beta 9 loop, wherein the FGF-9 variant incorporates one of the amino acid sequences set forth in SEQ ID NO: 11, 13, 14, 15, 16 or 17. | ||
| 申请公布号 | US8916522(B2) | 申请公布日期 | 2014.12.23 |
| 申请号 | US201313954347 | 申请日期 | 2013.07.30 |
| 申请人 | ProChon Biotech Ltd. | 发明人 | Bogin Oren;Yayon Avner |
| 分类号 | A61K38/18;C07K14/00;C07K14/50;C07K14/575 | 主分类号 | A61K38/18 |
| 代理机构 | Brown Rudnick LLP | 代理人 | Brown Rudnick LLP ;Meyers Thomas C. |
| 主权项 | 1. A method of treating achondroplasia comprising: administering to an individual a pharmaceutical composition comprising a therapeutically effective amount of a fibroblast growth factor 9 (FGF-9) variant comprising an amino acid sequence selected from one of the sequences set forth in SEQ ID NO: 11, 13, 14, 15, 16 and 17. | ||
| 地址 | Waltham MA US | ||