<i>Porphyromonas gingivalis </i>polypeptides useful in the prevention of periodontal disease

摘要

The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.

主权项

1. A method of treating a subject having a P. gingivalis infection and/or periodontal disease comprising administering to the subject a composition comprising (a) an effective amount of a polypeptide that comprises the amino acid sequence of SEQ ID NO: 3 or a variant of SEQ ID NO: 3 consisting of conservative amino acid substitutions to SEQ ID NO: 3 that is at least 90% identical to SEQ ID NO: 3, wherein the variant polypeptide induces the production of an antibody that specifically binds to the polypeptide of SEQ ID NO:3 and (b) a pharmaceutically acceptable carrier.