| 主权项 |
1. A compound having the structure of Formula I, or a pharmaceutically acceptable salt thereof: wherein: X is a 5- to 14-membered heteroaryl containing 1-3 heteroatoms; R1 is hydrogen, halogen, C1-C6alkyl, C3-C6cycloalkyl, or C2-C6alkenyl; wherein said alkyl, cycloalkyl or alkenyl is optionally substituted with one to three substituents each independently selected from the group consisting of fluoro, hydroxy and C1-C6alkoxy; A is a C3-C6cycloalkyl or a 4- to 10-membered heterocycloalkyl; wherein said cycloalkyl or heterocycloalkyl is optionally substituted with one to three substituents each independently selected from the group consisting of halogen and C1-C6alkyl; R2a and R2b for each occurrence is independently hydrogen, fluoro, cyano, C1-C6alkyl, C2-C6alkenyl, C3-C6cycloalkyl, C4-C8bicycloalkyl, C2-C6alkynyl or phenyl; wherein said alkyl, alkenyl, cycloalkyl, bicycloalkyl, alkynyl or phenyl is optionally substituted with one to three substituents each independently selected from the group consisting of cyano, C1-C3alkyl and fluoro; or R2a and R2b together with the carbon to which they are bonded form a 3- to 5-membered cycloalkyl optionally substituted with one to three of R8; R3 is hydrogen, halogen, C1-C6alkyl, C2-C6alkenyl, —(C(R10)2)t—(C3-C6cycloalkyl), —(C(R10)2)t-(4- to 10-membered heterocycloalkyl), —(C(R10)2)t—(C6-C10aryl), —(C(R10)2)t-(5- to 10-membered heteroaryl) or —(C(R10)2)t—OR12; wherein said alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one to five of R11; R4a and R4b are each independently hydrogen, or C1-C6alkyl, wherein said alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of, cyano and fluoro; R5a and R5b for each occurrence are each independently hydrogen, or C1-C6alkyl, wherein said alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of cyano and fluoro; R6, R7 and R8 are each independently hydrogen, —CF3, cyano, halogen, C1-C6alkyl, or —OR9; provided that R6 and R7 cannot both be —OH; R9 is hydrogen, or C1-C6alkyl; wherein said alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of cyano and fluoro; each R10 is independently hydrogen, halogen, cyano, C1-C6alkyl, or —SF5; wherein said alkyl is optionally substituted with one to three fluoro; each R11 is independently hydrogen, halogen, —SF5, —Si(CH3)3, OR12, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, —(C(R10)2)t—(C3-C6cycloalkyl), —(C(R10)2)t—(C6-C10aryl) or —(C(R10)2)t-(5- to 10-membered heteroaryl) wherein said —Si(CH3)3, alkyl, alkenyl, or alkynyl, cycloalkyl, aryl or heteroaryl is optionally substituted with one to five substituents each independently selected from the group consisting of halogen and —CF3; each R12 is hydrogen, C1-C6alkyl, —(C(R13)2)n—(C3-C6cycloalkyl), —(C(R13)2)n-(4- to 10-membered heterocycloalkyl), —(C(R13)2)n—(C6-C10aryl), or —(C(R13)2)n-(5- to 10-membered heteroaryl); wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one to five of R14; each R13 is independently hydrogen, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, halogen, cyano, —CF3, or —OCF3; R14 is independently hydrogen, —CF3, cyano, halogen or C1-6alkyl; wherein said alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of hydroxy, cyano and fluoro; and each t or n is an integer independently selected from 0, 1, 2 or 3; each z is 1; each y is an integer independently selected from 0, 1, 2, 3 or 4. |
