发明名称 |
CAPSÍDEO, MISTURA DE CAPSÍDEOS, PROTEÍNA QUIMÉRICA, MÉTODOS PARA PRODUZIR O CAPSÍDEO, E PARA PRODUZIR A MISTURA DE CAPSÍDEOS, E, COMPLEXO DE HEMICIANINA DE LAPA E EPÍTOPO L2 DE PAPILOMAVÍRUS HUMANO 16. |
摘要 |
<p>Disclosed is a vaccine antigen capable of inducing a cross-reacting and neutralizing antibody directed against a high-risk-type human papillomavirus. Specifically disclosed are: a chimeric protein comprising an L2-epitope of a human papillomavirus (HPV) type-16 inserted in a loop region of a human papilloma virus type-16 L1 protein; and a capsid which is an aggregate of the chimeric protein. The loop region to which the L2-epitope is to be inserted is located between an amino acid residue at position-430 and an amino acid residue at position-433. The L2-epitope has an amino acid sequence represented by any one of the following formulae: LYKTCKQAGTCPPDIIPKVEG (18-32 L2-epitope); GGLGIGTGSGTGGRTGYIPL (56-75 L2-epitope); and DPVGPLDPSIVSLVEESSFI (96-115 L2-epitope).</p> |
申请公布号 |
BRPI0813309(A2) |
申请公布日期 |
2014.12.23 |
申请号 |
BR2008PI13309 |
申请日期 |
2008.06.25 |
申请人 |
JAPAN HEALTH SCIENCES FOUNDATION |
发明人 |
TADAHITO KANDA;KAZUNARI KONDO |
分类号 |
C07K14/025;A61K39/12;A61P35/00;C07K14/435;C07K19/00;C12N15/09;C12P21/02 |
主分类号 |
C07K14/025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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