COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, MÉTODOS PARA MODULAR A ATIVIDADE DE UM RECEPTOR P2X7, PARA TRATAR UMA CONDIÇÃO, PARA INIBIR A MORTE DE CÉLULAS GANGLIÔNICAS RETINAIS, PARA PROMOVER PERDA DE PESO,E PARA DETERMINAR A PRESENÇA OU AUSÊNCIA DE RECEPTOR P2X7 EM UMA AMOSTRA, PREPARAÇÃO FARMACÊUTICA ACONDICIONADA, USO DE COMPOSTO OU SAL OU HIDRATO DO MESMO.

摘要

5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.