| 发明名称 |
ARTIFICIAL ANTIGEN PRESENTING CELLS HAVING A DEFINED AND DYNAMIC SHAPE |
| 摘要 |
Compositions and methods comprising asymmetrical artificial antigen presenting cells (aAPCs) are disclosed. The non-spherical aAPCs more closely mimic endogenous cell-cell interactions and can be used for antigen-specific immunotherapy. |
| 申请公布号 |
US2014370099(A1) |
申请公布日期 |
2014.12.18 |
| 申请号 |
US201214363955 |
申请日期 |
2012.12.10 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
Green Jordan J.;Sunshine Joel C.;Perica Karlo;Schneck Jonathan |
| 分类号 |
A61K9/16;B29B9/12;A61K39/00;A61K39/12;A61K39/02;A61K39/002 |
主分类号 |
A61K9/16 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An artificial antigen presenting cell (aAPC) comprising:
(a) a three-dimensional microparticle or nanoparticle having an asymmetrical shape that mimics a shape of a cell or a microorganism; and (b) one or more molecules capable of interacting with one or more T cell receptors (TCRs) of a T cell. |
| 地址 |
BALTIMORE MD US |
