| 发明名称 |
Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis |
| 摘要 |
The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro-inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat/prevent sepsis and/or hemorrhagic shock. |
| 申请公布号 |
US2014371299(A1) |
申请公布日期 |
2014.12.18 |
| 申请号 |
US201414475389 |
申请日期 |
2014.09.02 |
| 申请人 |
Senesco Technologies, Inc. |
发明人 |
THOMPSON JOHN E.;TAYLOR CATHERINE;DINARELLO CHARLES A. |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method of treating sepsis in a subject, comprising administering an eIF5A1 siRNA to the subject in an amount sufficient to decrease expression of pro-inflammatory cytokines in the subject, thereby treating sepsis in the subject. |
| 地址 |
New Brunswick NJ US |
