| 发明名称 |
GLYCOSYLATED POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME |
| 摘要 |
The object of the present invention is to provide a glycosylated polypeptide having uniform sugar chain structure which has interferon β activity. It was found that a glycosylated polypeptide having uniform sugar chain structure as well as having interferon β activity can be prepared by a method comprising a step of synthesizing a glycosylated peptide fragment and at least two peptide fragments and a step of linking the glycosylated peptide fragment and the at least two peptide fragments. |
| 申请公布号 |
US2014369964(A1) |
申请公布日期 |
2014.12.18 |
| 申请号 |
US201214347222 |
申请日期 |
2012.09.28 |
| 申请人 |
GLYTECH, INC. |
发明人 |
Sakamoto Izumi;Fukae Kazuhiro;Tezuka Katsunari;Tazuru Keisuke;Maeda Masatoshi;Kajihara Yasuhiro;Tsuji Takashi |
| 分类号 |
C07K14/565;C07K1/107;A61K38/21 |
主分类号 |
C07K14/565 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A glycosylated polypeptide chain characterized in that said glycosylated polypeptide is a polypeptide selected from the group consisting of:
(a) a polypeptide consisting of the amino acid sequence represented by SEQ ID NO. 1; (b) a polypeptide consisting of the amino acid sequence represented by SEQ ID NO. 1 having one or a few amino acids deleted, substituted, or added; (c) an interferon β analog; and (d) a polypeptide having 80% or more homology with a polypeptide consisting of the amino acid sequence represented by SEQ ID NO. 1;wherein the polypeptide has a sugar chain at the amino acid corresponding to position 80 in interferon β and has interferon β activity, and
said glycosylated polypeptide has substantially uniform sugar chains. |
| 地址 |
Kyoto JP |
