发明名称 |
USE OF THE CD2 SIGNALING DOMAIN IN SECOND-GENERATION CHIMERIC ANTIGEN RECEPTORS |
摘要 |
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions. |
申请公布号 |
US2014370045(A1) |
申请公布日期 |
2014.12.18 |
申请号 |
US201314375999 |
申请日期 |
2013.02.22 |
申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
June Carl H.;Scholler John;Posey, Jr. Avery D. |
分类号 |
C07K14/725;C12N15/85;C07K14/705 |
主分类号 |
C07K14/725 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the costimulatory signaling region comprises the CD2 signaling domain. |
地址 |
Philadelphia PA US |