发明名称 |
3HP TOLERANCE |
摘要 |
Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione- dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway. |
申请公布号 |
WO2014198841(A1) |
申请公布日期 |
2014.12.18 |
申请号 |
WO2014EP62267 |
申请日期 |
2014.06.12 |
申请人 |
TECHNICAL UNIVERSITY OF DENMARK |
发明人 |
KILDEGAARD, KANCHANA RUEKSOMTAWIN;BORODINA, IRINA;FÖRSTER, JOCHEN;NIELSEN, JENS |
分类号 |
C12N9/02;C12N9/00;C12N9/04;C12P7/42;C12P7/52 |
主分类号 |
C12N9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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