Useful combinations of monobactam antibiotics with beta-lactamase inhibitors

摘要

USEFUL COMBINATIONS OF MONOBACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORS Abstract A pharmaceutical composition, comprising a combination of an antibiotically active 5 compound of the formula (1): with a -lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another p-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI). N'O ~ ~jR2 ,0 N O 'R1