| 主权项 |
1. A compound represented by the following structural formula:or a pharmaceutically acceptable salt thereof, wherein:
each R1 is independently selected from H, -halogen, —CN, —NO2, —ORc, —NRaRb, —S(O)iRc, —NRdS(O)iRc, —S(O)iNReRf, —C(═O)ORc, —OC(═O)ORc, —C(═S)ORc, —O(C═S)Rc, —C(═O)NReRf, —NRdC(═O)Rc, —C(═S)NReRf, —NRdC(═S)Rc, —NRd(C═O)ORc, —O(C═O)NReRf, —NRd(C═S)ORc, —O(C═S)NReRf, —NRd(C═O)NReRf, —NRd(C═S)NReRf, —C(═S)Rc, —C(═O)Rc, heterocycloalkyl or alkyl, wherein the heterocycloalkyl or the alkyl is optionally substituted with 1 to 3 substituents independently selected from -halogen, —CN, —NO2, —ORc, —NRaRb, —S(O)iRc, —NRdS(O)iRc, —S(O)iNReRf, —C(═O)ORc, —OC(═O)ORc, —C(═S)ORc, —O(C═S)Rc, —C(═O)NReRf, —NRdC(═O)Rc, —C(═S)NReRf, —NRdC(═S)Rc, —NRd(C═O)ORc, —O(C═O)NReRf, —NRd(C═S)ORc, —O(C═S)NReRf, —NRd(C═O)NReRf, —NRd(C═S)NReRf, —C(═S)Rc and —C(═O)Rc; each R2 is independently selected from: —(CH2)0-2C(═O)NR4(CH2)0-2Z—R5, —(CH2)0-2NR4C(═O)(CH2)0-2Z—R5 and —(CH2)0-2NR4(C═O)NR4(CH2)0-2Z—R5; R3 is or —O—(C1-C6)alkyl-NRaRb; or R3 taken together with an instance of R1 and the phenyl ring to which they are attached form a fused ring heteroaryl or heterocycloalkyl, wherein the heteroaryl or heterocycloalkyl are optionally substituted with 1 to 4 (C1-C3) alkyl, oxo, hydroxyl, spirocycloalkyl and spiroheterocycloalkyl, provided that R3 is meta or para to the indazole ring; W is —O—, —S(O)i— or —CR8R9—; X is —O—, —CR8R9—, —NR11— or —S(O)i—; Y is —O—(CH2)r—, —NR12—(CH2)r—, —CH2— or —S(O), —(CH2)r—; R4 is H or an alkyl group optionally substituted with 1 to 3 substituents independently selected from halogen, hydroxy and (C1-C3)alkoxy; R5 is alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, each of which is optionally substituted with 1 to 3 groups individually represented by R15 or R16; Z is a bond or —CR13R14—; R6 is halogen, hydroxyl, (C1-C3)alkyl, (C1-C3)alkoxy, (C1-C3)alkyl-ORc or —NRaRb; or two instances of R6 on the same carbon are taken together form ═O; or two instances of R6 on different carbons, together with the ring to which they are attached, form a bridged bicyclic group; R7 is —H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, heterocycloalkyl, heterocycloalkyl(C1-C6)alkyl, —C(═O)Rc or —C(═O)ORc, wherein each of the (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, heterocycloalkyl and heterocycloalkyl(C1-C6)alkyl groups is optionally substituted with 1 to 4 substituents independently selected from halogen, hydroxy, (C1-C3)alkoxy and —C(═O)NReRf; R8 and R9 are each independently selected from —H, —ORc, (C1-C6)alkyl, and heterocycloalkyl, wherein the (C1-C6)alkyl group and heterocycloalkyl are optionally substituted with 1 to 3 substituents independently selected from halogen, hydroxy and (C1-C3)alkoxy; R10 is H, (C1-C3)alkyl, or heterocycloalkyl, or is absent when the nitrogen to which it is attached is attached directly to the moiety; wherein the heterocycloalkyl is optionally substituted with 1 to 3 substituents independently selected from halogen, hydroxy and (C1-C3)alkoxy; R11 is —H, (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, heterocycloalkyl, heterocycloalkyl(C1-C6)alkyl, —C(═O)Rc or —C(═O)ORc, wherein each of the (C1-C6)alkyl, cycloalkyl, cycloalkyl(C1-C6)alkyl, heterocycloalkyl and heterocycloalkyl(C1-C6)alkyl groups is optionally substituted with 1 to 3 substituents independently selected from halogen, hydroxy, (C1-C3)alkoxy and —C(═O)NReRf; R12 is —H or (C1-C3)alkyl; R13 and R14 are each independently selected from —H, alkyl, —ORc, —NRaRb, —(C1-C3)alkylene-NRaRb, —(C1-C3)alkylene-ORc, —(C1-C3)alkylene-OH, cycloalkyl, —O-cycloalkyl and heterocycloalkyl, wherein each of the cycloalkyl or heterocycloalkyl groups is optionally substituted with 1 to 3 substituents independently selected from (C1-C3)alkyl and (C1-C3)alkoxy, provided that R13 and R14 are not both selected from —ORc and —NRaRb; wherein each of the alkyl is optionally substituted with 1 to 3 substituents independently selected from halogen, (C1-C3)alkyl, and (C1-C3)alkoxy. each R15 and R16 are independently selected from halogen, —CN, —NO2, ═O, —ORc, —NRaRb, —S(O)iRc, —NRdS(O)iRc, —S(O)iNReRf, C(═O)ORc, —OC(═O)ORc, —C(═S)ORc, —O(C═S)Rc, —C(═O)NReRf, —NRdC(═O)Rc, —C(═S)NReRf, —NRdC(═S)Rc, —NRd(C═O)ORc, —O(C═O)NReRf, —NRd(C═S)ORc, —O(C═S)NReRf, —NRd(C═O)NReRf, —NRd(C═S)NReRf, —C(═S)Rc, —C(═O)Rc, (C1-C6)alkyl, aryl, aryl(C1-C3)alkyl, heterocycloalkyl and heteroaryl; wherein each (C1-C6)alkyl, aryl, aryl(C1-C3)alkyl, heterocycloalkyl and heteroaryl represented by R15 is optionally substituted with 1 to 3 substituents independently selected from -halogen, —CN, —ORc, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy, (C1-C3)alkoxy(C1-C6)alkyl, 3 to 8 membered heterocycloalkyl and 3 to 8 membered heteroaryl; each R21 is halogen; Ra and Rb are each independently selected from —H and (C1-C6)alkyl, optionally substituted with 1 to 3 substituents independently selected from halogen, hydroxy, —NRgRh and (C1-C3)alkoxy; Rc is —H, cycloalkyl, or (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with 1 to 3 substituents independently selected from halogen, —NRgRh, hydroxy and (C1-C3)alkoxy; Rd is H or (C1-C6)alkyl, optionally substituted with 1 to 3 substituents independently selected from halogen, —NRgRh, hydroxy and (C1-C3)alkoxy; Re and Rf are each independently selected from —H and (C1-C6)alkyl optionally substituted with 1 to 3 substituents independently selected from halogen, —NRgRh, hydroxy and (C1-C3)alkoxy; or Re and Rf, together with the nitrogen to which they are attached, form a 3-8 membered ring optionally substituted with 1 to 3 substituents independently selected from halogen, —NRgRh, —CN, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy, and (C1-C3)alkoxy(C1-C6)alkyl; Rg and Rh are each independently selected from —H, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl and (C1-C3)alkoxy(C1-C6)alkyl; i is 0, 1 or 2; n′ is an integer from 1 to 4; n″ is an integer from 0 to 2, provided that n′+n″≦4; m is an integer from 1 to 4; each p is 1, 2 or 3; q is 0, 1 or 2; and r is 0, 1, 2 or 3. |
