发明名称 |
METHODS OF DOWNREGULATING TRANSLOCATED ONCOGENE EXPRESSION USING BROMODOMAIN INHIBITORS |
摘要 |
Disclosed herein are novel methods and compositions useful for inhibiting interaction between a bromodomain protein and an immunoglobulin (Ig) regulatory element. The methods and compositions are particularly useful for downregulating expression of an oncogene translocated with an Ig locus, as well as for treating a cancer (e.g., hematological malignancy) characterized by increased expression of an oncogene which is translocated with an Ig locus. Also disclosed herein are methods and assays for identifying agents that interfere with binding of bromodomain proteins to Ig regulatory elements, as well as methods and assays for identifying inhibitors of bromodomain |
申请公布号 |
US2014371157(A1) |
申请公布日期 |
2014.12.18 |
申请号 |
US201214342265 |
申请日期 |
2012.08.30 |
申请人 |
Young Richard A.;Rahl Peter B.;Bradner James |
发明人 |
Young Richard A.;Rahl Peter B.;Bradner James |
分类号 |
A61K38/02;A61K31/551;A61K31/713;A61K31/7088;G01N33/50 |
主分类号 |
A61K38/02 |
代理机构 |
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代理人 |
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主权项 |
1. (canceled) |
地址 |
Boston MA US |