发明名称 |
METHODS AND COMPOSITIONS RELATED TO T-CELL ACTIVITY |
摘要 |
Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients. T cell anergy is a hyporesponsive state induced by TCR engagement in the absence of costimulation (Schwartz, 2003). Anergy induction was initially observed in vitro using chemically-fixed antigen presenting cells (APCs). Subsequently, it was found that anergy could be induced by immobilized anti-CD3 mAb or calcium ionophores (such as ionomycin) in vitro, and by superantigen and soluble antigenic peptide in vivo. Indirect evidence has suggested that T cell dysfunction in the tumor microenvironment and establishment of transplant tolerance is partially due to T cell anergy (Gajewski et al., 2011 ). |
申请公布号 |
WO2014144666(A3) |
申请公布日期 |
2014.12.18 |
申请号 |
WO2014US29173 |
申请日期 |
2014.03.14 |
申请人 |
THE UNIVERSITY OF CHICAGO |
发明人 |
ZHENG, YAN;ZHA, YUANYUAN;SPAAPEN, ROBERT, M.;GAJEWSKI, THOMAS, F. |
分类号 |
C12N5/0783 |
主分类号 |
C12N5/0783 |
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