发明名称 ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTICANCER DERIVATIVES OF TRIPTOLIDE AND NANOSPHERES THEREOF
摘要 This invention relates to uses of conjugates of triptolide nanoprodrugs in cancer immunotherapy, specifically compound such as D-I or D-II wherein X1 is a antioxidant, an anti-inflammatory or an anticancer agent and nanospheres thereof, and A is be selected from the group consisting of branched and unbranched alkyl, branched and unbranched alkenyl, branched and unbranched alkynyl, heteroatom-containing branched and unbranched alkyl, heteroatom-containing branched and unbranched alkenyl, heteroatom-containing branched and unbranched alkynyl, aryl, cyclic aliphatic, cyclic aromatic, heterocyclic, and aromatic heterocyclic groups.
申请公布号 WO2014201026(A2) 申请公布日期 2014.12.18
申请号 WO2014US41752 申请日期 2014.06.10
申请人 CEDARS-SINAI MEDICAL CENTER 发明人 YU, JOHN S.;LEE, BONG SEOP;ZHANG, LEI
分类号 A61K31/385;C07D493/22 主分类号 A61K31/385
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