COMPOSITIONS AND METHODS FOR ENHANCING VIRUS REPLICATION
摘要
Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. An oncolytic virus having a genome that includes an open reading frame that encodes FGF2 protein or a functional variant thereof is also described.
申请公布号
CA2915045(A1)
申请公布日期
2014.12.18
申请号
CA20142915045
申请日期
2014.06.16
申请人
OTTAWA HOSPITAL RESEARCH INSTITUTE
发明人
ILKOW, CAROLINA SOLANGE;LEBOEUF, FABRICE;BELL, JOHN CAMERON;DIALLO, JEAN-SIMON;ARULANANDAM, ROZANNE