摘要 |
A method of treating cancer, inflammatory disease, and autoimmune disease by administering to a subject in need thereof an effective amount of one or more 1,5-dipenylpenta-1,4-dien-3-one compounds. The compounds feature either or both of the phenyl rings being substituted with hydroxyl, diethyl(2-alkoxyethyl)amine, 1-(2-alkoxyethyl)piperidine, sulfonate, phosphinate, or phosphate. |
主权项 |
1. A method for treating cancer, inflammatory disease, or autoimmune disease, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein each of X and Y, independently, is H, alkyl, or halo; and each of R1, R2, R3, R4, R5, R1′, R2′, R3′, R4′, and R5′, independently, is H, alkyl, halo, OH, Rc—O—, RdS(O)2—O—, (Rd)2P(O)—O—, or (RdO)2P(O)—O—, Rc being unsubstituted alkyl or alkyl substituted with halo, OH, alkoxy, amino, or cycloalkyl, and Rd being H, OH, C2-C10 alkyl, or alkoxy; in which at least one of R1, R2, R3, R4, R5, R1′, R2′, R3′, R4′, and R5′ is RdS(O)2—O—, (Rd)2P(O)—O—, or (RdO)2P(O)—O—. |