Use of Liposomal WNT Composition to Enhance Osseointegration

摘要

Methods and compositions are provided for the therapeutic use of Wnt proteins, for enhancing bone growth and regeneration, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.

主权项

1. A method of accelerating osteogenesis in a mammal, the method comprising:
administering to the mammal an effective dose of a wnt polypeptide comprising a lipid moiety at a site of desired osteogenesis in the mammal, wherein the wnt protein is inserted in the non-aqueous phase of a lipid structure.