IL-12 FOR RADIATION PROTECTION AND RADIATION-INDUCED TOXICITY MITIGATION

摘要

Aspects and embodiments of the instant disclosure provide therapeutic methods and compositions comprising inter-leukin 12 (IL-12) useful for treating radiation-induced damage in a subject. In particular, the instant disclosure provides methods and compositions for radiation protection and/or radiation toxicity mitigation for the treatment of acute radiation syndrome and radiation induced toxicity associated with the treatment of cutaneous T-cell lymphoma.

主权项

1. A method of protecting a subject from system, organ, tissue, or cellular damage, following exposure of the subject to ionizing radiation, the method comprising:
administering a therapeutically effective amount of a pharmaceutical composition comprising substantially isolated rIL-12 to the subject, whereby the system, organ, tissue, and/or cellular damage due to radiation is diminished.