主权项 |
1. An isolated double stranded RNA molecule comprising annealed complementary strands, wherein at least one of said strands comprises a polyribonucleotide selected from the group consisting of:
(i) polyribonucleotides complementary to at least 21 contiguous nucleotides of a target gene represented by any of SEQ ID NOs: 3, 795, 890, 1073, 1684, and 2366, (ii) polyribonucleotides complementary to at least 21 contiguous nucleotides of a target gene encoding the amino acid sequence represented by any of SEQ ID NO: 4, 796, 891, 1074, 1685, and 2367, and (iii) polyribonucleotides having at least 80% sequence identity with the polyribonucleotides of (i) or (ii), wherein said double stranded RNA molecule causes down-regulation of said target gene. |