METHODS FOR TREATING, DIAGNOSING AND MONITORING ALZHEIMER'S DISEASE

摘要

The invention provides methods of diagnosis and prognosis of Alzheimer' disease (AD) in a subject comprising detecting the presence or absence of one or more genetic variations in a sample from the subject, wherein the presence of the genetic variation indicates that the subject is afflicted with, or at risk of developing, AD. Methods of predicting the response of a subject to therapeutic agents for the treatment of AD are also provided.

主权项

1. A method for detecting the presence or absence of a genetic variation indicative of Alzheimer's disease (AD) in a subject, comprising:
(a) contacting a sample from the subject with a reagent capable of detecting the presence or absence of a genetic variation in a gene selected from the genes encoding IL6R, NTF4 and UNC5C, or a gene product thereof; and (b) determining the presence or absence of the genetic variation, wherein the presence of the genetic variation indicates that the subject is afflicted with, or at risk of developing, AD.