发明名称 Method of treating cancer with Dll4 antagonist and chemotherapeutic agent
摘要 <p>The invention provides methods for treating various types of cancer/tumor by administering the combination of DII4 antagonists, in particular, DII4 antibodies and fragments thereof that specifically bind human DII4, and chemotherapeutic agents. Such combination therapies exhibit synergistic effects compared to the treatment with either agent alone. Thus, the methods of the invention are particularly beneficial for cancer patients who have low tolerance to the side effects caused by high dosages required for the treatment by either agent alone, by being able to reduce effective dosages. Pharmaceutical compositions and kits containing DII4 antagonists and chemotherapeutic agents are also provided.</p>
申请公布号 AU2010266004(A8) 申请公布日期 2014.12.18
申请号 AU20100266004 申请日期 2010.06.25
申请人 REGENERON PHARMACEUTICALS, INC. 发明人 NOGUERA-TROISE, IRENE;THURSTON, GAVIN;THIBAULT, ALAIN
分类号 C07K16/22;A61K39/395 主分类号 C07K16/22
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