METHODS AND COMPOSITIONS FOR RAPID TRANSBUCCAL DELIVERY OF ACTIVE AGENTS

摘要

A method of rapid transbuccal delivery of an active agent into the bloodstream is provided. The method can include providing a pharmaceutical composition comprising the active agent, resin and a volatile solvent and, optionally, water. In some embodiments, the method achieves a Tmax 60 minutes or less, an onset of therapeutic effect of 60 minutes or less, and/or achieves therapeutic serum levels of the active agent within 60 minutes or less. Related compositions also are provided.

主权项

1. A method for rapid transbuccal delivery of an active agent into the bloodstream, comprising bucally administering to a subject in need thereof, a pharmaceutical composition comprising (i) a pharmaceutically active agent, (ii) a resin, (iii) a volatile solvent, and optionally (iv) water.