PHARMACEUTICAL FORMULATION AND METHOD FOR TREATING ACID CAUSED GASTROINTESTINAL DISORDERS

摘要

Pharmaceutical formulations in the form of a powder for suspension comprising at least one proton pump inhibitor in micronized form; at least one antacid; and at least one suspending agents are provided herein. Also provided herein are methods for making and using pharmaceutical formulations comprising at least one proton pump inhibitor and at least one antacid.

主权项

1. A method of making a pharmaceutical formulation for oral administration comprising:
(a) making a first blend by dry blending at least one acid-labile substituted bicyclic aryl-imidazole proton pump inhibitor in micronized form with at least one bicarbonate salt of a Group IA metal, wherein (i) at least 80% of the micronized proton pump inhibitor is less than 40 μm in diameter; and (ii) the dry blending coats at least some of the bicarbonate salt with at least some of the micronized proton pump inhibitor; and (b) blending the first blend with at least one other excipient comprising xanthan gum in an amount of about 50 mg to about 150 mgs.