发明名称 |
STABILIZED POLYPEPTIDE INSULIN RECEPTOR MODULATORS |
摘要 |
Provided herein are stablized α-CT polypeptides comprising an alpha-helical segment, and wherein the polypeptide is of Formula (I-1) or Formula (I-2): Rf-[XAA]s-XA1-XA2-XA3-XA4-XA5-XA6-XA7-XA8-XA9-XA10-XA11-XA12-XA13-XA14-[XAA]t-Re (I-1) Rf-[XAA]s-XC1-XC2-XC3-XC4-XC5-XC6-XC7-XC8-XC9-XC10-XC11-XC12-XC13-XC14- XC15-XC16-XC17-XC18-XC19-XC20-[XAA]t-Re (I-2) wherein the α-CT polypeptide binds to the insulin receptor, and wherein the α-CT polypeptide includes at least one staple (i.e. two cross-linked amino acids) and/or at least one stitch (i.e. three cross-linked amino acids). Further provided are insulin analogues including the stapled or stitched α-CT polypeptides, pharmaceutical compositions thereof, methods of use, e.g., methods of treating a diabetic condition or complications thereof. |
申请公布号 |
WO2014201370(A1) |
申请公布日期 |
2014.12.18 |
申请号 |
WO2014US42329 |
申请日期 |
2014.06.13 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
VERDINE, GREGORY, L.;HILINSKI, GERARD;LIANG, REBECCA, YUE;NAGEL, YVONNE, ALICE;ZHOU, MINYUN |
分类号 |
C07K14/62;C07K7/64;C07K14/72 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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