| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide a compound useful as an active ingredient of a therapeutic pharmaceutical composition for a disease involved in RANKL/RANK signals, such as osteoporosis, osteopenia and rheumatoid arthritis.SOLUTION: The prevent inventors have been studied about a compound having RANKL/RANK signal inhibitory activity, confirmed that a 2-(pyridine-2-yl) pyrimidine-4-amine compound or a salt thereof has potent RANKL/RANK signal inhibitory activity, improves RANKL-induced bone mineral density reduction and is effective in an osteoporosis model, and completed the present invention. The 2-(pyridine-2-yl) pyrimidine-4-amine compound or a salt thereof of the present invention has RANKL/RANK signal inhibitory activity and can be used as a therapeutic agent for a disease involved in RANKL/RANK signals, such as osteoporosis, osteopenia and rheumatoid arthritis.</p> |
