BENZIMIDAZOLE-BASED POLY(ADPribose)POLYMERASE INHIBITOR

摘要

PROBLEM TO BE SOLVED: To provide a compound inhibiting poly(ADPribose)polymerase (PARP) activity, a composition containing the compound, and a disease-therapeutic method using them.SOLUTION: A compound represented by the formula I or a salt of the compound is provided. [In the formula, A1 is heteroaryl substituted by A2 and uncondensed or condensed with benzene, heteroallene or R1A; R1A is cycloalkane, heterocyclic alkane or the like; A2 is heteroaryl, heterocyclic alkyl or heterocyclic alkenyl, each uncondensed or condensed with benzene, heteroallene or R2A; R2A is cycloalkane, cycloalkene, heterocyclic alkane or heterocyclic alkene; B1 is hydrogen, C(O)NH2, SO2 NH2 or the like; and C1, D1 and E1 is each independently hydrogen, NO2, CN, C(O)NH2, NH2, OH, F, Cl, Br, I or the like.]