主权项 |
1. A method for performing thermoablation, comprising the steps of contacting a target tissue region of a mammalian subject with a composition comprising a plurality of plasmonic nanoparticles under conditions such that an effective amount of the plasmonic nanoparticles localize to a domain of the target tissue region; and exposing the target tissue region to energy delivered from a nonlinear excitation surface plasmon resonance source in an amount effective to induce thermoablation of the domain of the target tissue region, wherein the nanoparticle comprises a coat on a surface of the nanoparticle, wherein the coat comprises a polar moiety, non-polar moiety, charged moiety, ionic moiety, basic moiety, acidic moiety, oxidative moiety, hydrophobic moiety, hydrophilic moiety, agonistic moiety, antagonistic moiety, or reactive moiety. |