发明名称 |
CODON SIGNATURE FOR NEUROMYELITIS OPTICA |
摘要 |
The present invention provides for the diagnosis and prediction of neuromyelitis optica (NMO) in subject utilizing a unique a codon signature in B cells that has now been associated with NMO and not with any other autoimmune disease. More particularly, the method may comprise the steps of (a) providing a 10 B-cell containing sample from a subject, or DNA or RNA isolated therefrom; (b) determining the VH1 and/or VH4 structure of VH1NH4-expressing B-cells from said subject, (c) determining the mutational frequency VH1 and/or VH4 genes; (d) identifying the presence or absence of a codon signature associated with NMO or risk of NMO; and (e) selecting patients exhibiting said codon signature. |
申请公布号 |
US2014371132(A1) |
申请公布日期 |
2014.12.18 |
申请号 |
US201214352473 |
申请日期 |
2012.10.18 |
申请人 |
The Board of Regents of the University of Texas System |
发明人 |
Monson Nancy |
分类号 |
C12Q1/68;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A method for selecting a human subject having or at risk of developing neuromyelitis optica (NMO) comprising:
(a) providing a B-cell containing sample from a subject, or DNA or RNA isolated therefrom; (b) determining the VH1 and/or VH4 structure of VH1/VH4-expressing B-cells from said subject, (c) determining the mutational frequency VH1 and/or VH4 genes; (d) identifying the presence or absence of a codon signature associated with NMO or risk of NMO; and (e) selecting patients exhibiting said codon signature. |
地址 |
Austin TX US |